Best Luteolin Supplements

Written and reviewed by the Harley Medic Editorial Team. Last updated 3 July 2026.

How we score. We rate every luteolin supplement out of 10 across five criteria — purity & source, dose, form & absorption, testing & transparency, and value — for a total out of 50. Purity and dose carry the most weight, because a “high-strength” label means little if the actual luteolin content or purity is low. Scores are editorial judgements based on published product information; confirm current specifications before buying.

Top of the table: the Welzo Ultra Purity Luteolin 500 scored highest overall, winning on dose and value while matching the field on purity and testing — a high 500 mg of luteolin per serving, third-party tested and UK-dispatched.

Luteolin — a flavonoid studied for antioxidant, anti-inflammatory and mast-cell-related properties — is one of the fastest-growing supplements in the longevity and wellness space. But quality varies enormously: doses run from 50 mg to 500 mg, purity from mediocre to 99%+, and some products hide their plant source. To cut through it, we scored six of the most credible options against the same five criteria. Here’s the full scorecard, the reviews behind it, and the science and safety you need.

Contents

• The scorecard
• The 6 best luteolin supplements, scored
• What is luteolin?
• Benefits & what the research shows
• How to choose
• Dosage & absorption
• Safety & interactions
• Stacking luteolin
• FAQs
• References

The Scorecard

Form = form & absorption. Specifications and prices change; confirm on each product page before buying.

The 6 Best Luteolin Supplements, Scored

1. Welzo Ultra Purity Luteolin 500 — 44/50

Score: Purity 9 · Dose 10 · Form 7 · Testing 9 · Value 9.

The Welzo Ultra Purity Luteolin 500 tops the table by winning the two most heavily-weighted criteria. Its 500 mg of luteolin per serving is the highest single-ingredient dose here (most rivals sit at 100–200 mg), earning full marks on dose. It’s third-party tested for identity, potency and contaminants, transparently labelled with no proprietary blend, GMP-made and dispatched from the UK with a returns policy — strong on testing and value. It only drops points on form, being a standard capsule rather than a liposomal delivery system, though its high dose more than compensates on total luteolin delivered.

Verdict: the best overall luteolin supplement on our scoring — high dose, clean and well-tested, at sensible value. View product →

2. Double Wood Luteolin — 41/50

Score: Purity 9 · Dose 6 · Form 7 · Testing 9 · Value 10.

Double Wood takes the value crown. Its luteolin is standardised to 98% from sophora japonica (not a peanut-shell source), every batch is cGMP-made and third-party tested for potency and contaminants, and the price per bottle is the lowest here. It loses ground only on dose, at 100 mg per serving. For a transparent, high-purity everyday luteolin at a keen price, it’s excellent.

Verdict: the best-value high-purity pick — just at a lower dose than our winner.

3. Vitality Pro Luteolin — 40/50

Score: Purity 10 · Dose 6 · Form 7 · Testing 9 · Value 8.

Vitality Pro earns the only perfect purity mark: a UK longevity brand whose recent batches are independently verified at up to 99.8% purity (sophora japonica), made to GMP and ISO 9001 standards, vegan and UK-dispatched. It frames luteolin within a senescence/CD38 context. Like the others at 100 mg, it scores mid-range on dose.

Verdict: the purity leader and a strong UK option, narrowly behind on dose and value.

4. Neurogan Liposomal Luteolin — 36/50

Score: Purity 8 · Dose 6 · Form 9 · Testing 7 · Value 6.

Neurogan tops the field on form, using a liposomal delivery system (100 mg per serving) to address luteolin’s poor water solubility. If you’d rather optimise absorption than push the raw dose, it’s the natural pick. It scores lower on value, since liposomal formats cost more per milligram of luteolin.

Verdict: the best absorption-focused option, at a premium per milligram.

5. NeuroProtek (Algonot) — 34/50

Score: Purity 7 · Dose 6 · Form 9 · Testing 7 · Value 5.

NeuroProtek is the well-known multi-flavonoid formula, combining luteolin with quercetin and rutin in an olive-oil base for absorption. It scores well on form and appeals to those wanting several flavonoids together, but as a premium-priced blend it’s marked down on value, and the individual luteolin dose is lower than a dedicated capsule.

Verdict: the established flavonoid-complex choice; premium, and not a high single-dose luteolin.

6. Horbaach Luteolin Complex — 34/50

Score: Purity 6 · Dose 8 · Form 6 · Testing 6 · Value 8.

Horbaach offers a solid 200 mg per serving at a budget price, scoring well on dose and value. It’s marked lower on purity and testing transparency versus the standardised leaders, so check the label and batch details — but as an accessible, higher-dose value option it earns its place.

Verdict: a budget-friendly higher-dose pick; verify purity and testing for your batch.

What Is Luteolin?

Luteolin is a plant flavone found in celery, parsley, chamomile, thyme, peppers and citrus, concentrated in supplements (commonly from sophora japonica, or in some products peanut shells) to provide far more than diet delivers. It’s studied as an antioxidant and, in laboratory research, interacts with inflammatory pathways (NF-κB, AP-1) and mast cells; it’s also described as a CD38 inhibitor and a senolytic, which is why it appears in longevity stacks. It can cross the blood-brain barrier, underpinning interest in its neuroprotective properties.

Benefits & What the Research Shows

Luteolin is most commonly taken for antioxidant support, help maintaining a normal inflammatory response, brain and immune wellness, mast-cell/histamine balance, and healthy-ageing (senescent-cell) support. It’s important to be honest about the evidence: much of it is preclinical. Laboratory studies show luteolin can block NF-κB and AP-1 inflammatory signalling,¹ and inhibit mast-cell release of histamine and cytokines.² Several of the most-cited human findings come from combination products (for example, palmitoylethanolamide with luteolin) in small trials.³ The reasonable takeaway: luteolin is a well-tolerated antioxidant flavonoid with encouraging early research, best chosen on quality and used with measured expectations — not as a treatment.

How to Choose

• Purity/standardisation: ideally 95%+ luteolin.
• Actual dose per serving: read the label, not just the headline number.
• Plant source: avoid peanut-shell-sourced luteolin if you have a peanut allergy; sophora japonica is a common alternative.
• Third-party testing for identity, potency and contaminants.
• Form: liposomal/lipid delivery or taking with fat helps absorption.
• Clean label & UK dispatch for quality and convenience.

Dosage & Absorption

There’s no official dose; luteolin is commonly used at 100–300 mg/day, with high-strength products (like our winner) providing up to 500 mg. Because luteolin is fat-soluble and poorly water-soluble, take it with a fat-containing meal, consider a lipid/liposomal format, and be consistent — effects build over 3–6 weeks. Start at the lower end if you’re new to it.

Safety & Interactions

• Generally well tolerated; mild digestive upset is the most common effect (take with food).
• May interact with blood thinners, some chemotherapy agents and certain antibiotics via cytochrome P450 inhibition — check with your GP or pharmacist.
• Avoid peanut-shell-sourced products with a peanut allergy.
• Not for use in pregnancy or breastfeeding without medical advice, or by under-18s.

Food supplements support — not replace — a balanced diet, a healthy lifestyle and professional medical advice.

Stacking Luteolin

Luteolin pairs logically with other antioxidant and longevity compounds. Closely related is apigenin, another flavonoid studied for anti-inflammatory and CD38 effects. For broader routines, people combine luteolin with antioxidant support such as astaxanthin, cellular-renewal compounds like spermidine, and — because luteolin may help preserve NAD+ via CD38 — an NMN precursor. Gut health also shapes immune tone, an area where Akkermansia and prebiotic pectin are discussed. Introduce one compound at a time.

FAQs

What is the best luteolin supplement?

On our scoring, the Welzo Ultra Purity Luteolin 500 (44/50) — a high 500 mg dose, third-party tested and UK-dispatched. Double Wood Luteolin (41/50) is the best-value high-purity alternative.

How did you rank them?

Each product scored out of 10 on purity, dose, form & absorption, testing & transparency, and value, for a total out of 50, with purity and dose weighted most heavily.

What is the best luteolin dosage?

Commonly 100–300 mg/day, up to 500 mg for high-strength products. Start low and take with food containing some fat.

Is liposomal luteolin better?

It can aid absorption of a fat-soluble flavonoid, but a higher-dose standard capsule may deliver more total luteolin. Weigh dose, purity and format together.

What should I look for?

High purity (95%+), a clear dose, third-party testing, GMP manufacturing, a stated plant source (peanut-shell vs sophora japonica) and UK dispatch.

Are there side effects or interactions?

Generally well tolerated; possible interactions with blood thinners and some chemotherapy agents. Consult a professional if you take medication, are pregnant or breastfeeding.

References

1. Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation in macrophages. PMC
2. Kritas SK, et al. Luteolin inhibits mast cell-mediated allergic inflammation. J Biol Regul Homeost Agents. PubMed
3. Co-ultramicronized palmitoylethanolamide/luteolin (combination formula) — randomised controlled trial. PMC

About this guide. Produced by the Harley Medic Editorial Team, which creates evidence-based health and supplement content grounded in peer-reviewed research. Our rankings are based on the transparent criteria described above. This content is for general education and is not personalised medical advice; always consult your own GP or pharmacist about your circumstances.

Transparency note: Harley Medic may have commercial relationships with some brands or retailers featured. This does not change our editorial scoring, which is based on the criteria and evidence described above.

Medical disclaimer: This article is for general information and educational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Food supplements should not replace a varied, balanced diet and healthy lifestyle. Always read the product label and consult your GP, pharmacist or a qualified healthcare professional before starting any new supplement — particularly if you are pregnant, breastfeeding, taking medication (including blood thinners or chemotherapy agents), or managing a health condition. Statements about luteolin reflect emerging nutritional research and are not intended to diagnose, treat, cure or prevent any disease. Prices, availability and specifications are correct at the time of writing and may change.