The Best Pills for Erectile Dysfunction

Written by HMI

May 22, 2023


Erectile Dysfunction (ED), also known as impotence, is a common male sexual health issue characterised by the consistent inability to achieve or maintain an erection adequate for satisfactory sexual performance. According to the Urology Care Foundation, ED affects up to 30 million men in the United States alone. It’s not just an ‘old man’s disease’. Age does increase risk but it’s also seen in younger men (source). The importance of addressing and treating ED extends beyond just sexual health; it’s integral to a man’s emotional health and quality of life. The condition can cause significant distress, lowered self-esteem, and relationship difficulties. Importantly, ED can also be a sign of underlying health problems, such as heart disease, that need treatment. Numerous treatment options are available, ranging from lifestyle modifications to medications and surgical procedures. This article will focus primarily on the pharmaceutical treatments for ED.

Understanding Erectile Dysfunction Medication

Erectile Dysfunction medications work by enhancing the effects of nitric oxide, a natural chemical your body produces that relaxes muscles in the penis, increasing blood flow and allowing an erection in response to sexual stimulation. The choice of ED medication is influenced by a variety of factors. Age, overall health, concurrent medications, lifestyle, and personal preferences all play a role. For example, a younger man with transient ED caused by stress may choose a different treatment compared to an older man with chronic ED due to diabetes or cardiovascular disease.

Overview of Erectile Dysfunction Medications

There are several ED medications available in the market today. The first-line treatments are phosphodiesterase type-5 (PDE5) inhibitors, including Sildenafil (Viagra), Tadalafil (Cialis), Vardenafil (Levitra, Staxyn), and Avanafil (Stendra). These medications are similar in many ways, but they also have distinct differences in terms of dosage, timing, side effects, and contraindications.

Key Comparisons of Erectile Dysfunction Medications

Let’s delve deeper into a detailed comparison of these medications based on various factors.

Sildenafil (Viagra)

Viagra, known generically as Sildenafil, is one of the most commonly prescribed medications for ED. It works by blocking the PDE5 enzyme, which is responsible for breaking down another compound called cGMP that promotes muscle relaxation in the penile arteries and corpus cavernosum, thus facilitating erection (source). Sildenafil is usually taken on an as-needed basis 30 minutes to one hour before sexual activity. Sildenafil typically costs £5-£15 depending on the dosage and supplier; for more information on where to buy sildenafil, head over to Welzo. The popular branded version of Sildenafil is Viagra or Viagra connect. Viagra connect can be purchased with prescription, and typically starts at £20+; check out Wezlo to buy Viagra Connect online. The maximum frequency of administration is once daily, and its effectiveness diminishes after four hours. It’s important to note that sexual stimulation is required for the medication to work. Common side effects of Sildenafil include headache, flushing, upset stomach, abnormal vision, stuffy or runny nose, back pain, muscle pain, or dizziness. Sildenafil can interact with other medications, particularly nitrates used for heart disease, leading to a dangerous drop in blood pressure. Therefore, it’s contraindicated in patients taking nitrates. It should also be used with caution in people with certain health conditions, including severe heart disease, low blood pressure, and liver disease. This detailed comparison of ED medications should serve as a guide in choosing the best treatment option. However, it’s crucial to remember that the decision should be made in consultation with a healthcare provider.

Tadalafil (Cialis)

Tadalafil, marketed as Cialis, is another popular PDE5 inhibitor. Similar to Sildenafil, it enhances the effect of nitric oxide in the body, thus aiding the relaxation of muscles in the penis and facilitating blood flow. However, Tadalafil stands out due to its prolonged duration of action (source). Cialis typically starts at £22, for further details on where to buy Cialis head to Welzo. The standard dose of Tadalafil can be taken as needed about 1-2 hours before sexual activity, but it’s unique in that a daily dose is also an option. This longer duration of action, up to 36 hours, provides a larger window of opportunity for sexual activity and allows for more spontaneity, which some men prefer. The side effects of Tadalafil are similar to those of Sildenafil and may include headache, upset stomach or heartburn, flushing, nasal congestion, back pain, and muscle aches. Interactions and contraindications also align closely with Sildenafil. It should not be used by individuals taking nitrates, certain antifungals, some antivirals, and a few other specific medications. People with heart disease or low blood pressure should use Tadalafil with caution.

Vardenafil (Levitra, Staxyn)

Vardenafil, sold under the brand names Levitra and Staxyn, is another choice in the arsenal against ED. Like its counterparts, Vardenafil increases blood flow to the penis by inhibiting the PDE5 enzyme (source). Vardenafil is usually taken one hour before sexual activity, with its effectiveness lasting around four to five hours. Like other ED drugs, sexual stimulation is required for it to work. To find out about purchasing Vardenafil, go to the buy Vardenafil section on Welzo. Side effects of Vardenafil may include flushing, headache, stuffy nose, upset stomach, or dizziness. Its interactions and contraindications mirror those of Sildenafil and Tadalafil; most notably, it shouldn’t be taken with nitrates or certain other medications, and caution should be exercised by those with specific health conditions.

Avanafil (Spendra)

Avanafil, marketed under the brand name Stendra and available to buy as Spedra, is the newest addition to the group of PDE5 inhibitors. This ED medication differentiates itself by having the quickest onset of action—taking effect in as little as 15 minutes for some men (source). Avanafil can be taken with or without food, ideally 15 to 30 minutes before sexual activity. Its effectiveness is typically maintained for up to six hours. Side effects are similar to those of the other PDE5 inhibitors and include flushing, headache, nasal congestion, back pain, and, rarely, changes in vision. Avanafil is contraindicated in the same situations as the other PDE5 inhibitors, with the additional caution that it should not be taken with certain antibiotics and antifungal medications. Each of these ED medications has its advantages and potential challenges.

A healthcare professional will be able to guide individuals towards the most suitable treatment, considering their overall health, lifestyle, preferences, and the specific nature of their ED. This comprehensive comparison, made possible by the experts at Welzo, the online medical journal, should help men and their healthcare providers make informed decisions about ED medication. However, it is important to note that medications are just one piece of the puzzle. Non-pharmaceutical interventions, including lifestyle changes and psychotherapy, can also play a critical role in managing ED.

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